Scarless wound healing programmed by core-shell microneedles

Effective reprogramming of chronic wound healing remains challenging due to the limited drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing timing in distinct healing stages. Herein, a core-shell structured microneedle array patch with programmed functions (PF-MNs) is designed to dynamically modulate the wound immune microenvironment according to the varied healing phases. Specifically, PF-MNs combat multidrug-resistant bacterial biofilm at the early stage via generating reactive oxygen species (ROS) under laser irradiation. Subsequently, the ROS-sensitive MN shell gradually degrades to expose the MN core component, which neutralizes various inflammatory factors and…

• NN
  National Natural Science Foundation of China

  Awards: 32101064, 52233013, 2021YFA0909900
• ZU
  Zhejiang University
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 2021FZZX001-47, 2021FZZX001