Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment
National University of Singapore · National University Health System · +2 more institutions
Abstract
Vascular cognitive impairment (VCI) describes a wide spectrum of cognitive deficits related to cerebrovascular diseases. Although the loss of blood flow to cortical regions critically involved in cognitive processes must feature as the main driver of VCI, the underlying mechanisms and interactions with related disease processes remain to be fully elucidated. Recent clinical studies of cerebral blood flow measurements have supported the role of chronic cerebral hypoperfusion (CCH) as a major driver of the vascular pathology and clinical manifestations of VCI. Here we review the pathophysiological mechanisms as well as neuropathological changes of CCH. Potential interventional strategies for VCI are also…
Citation impact
- FWCI
- 21.51
- Percentile
- 100%
- References
- 317
Authors
12- VRVismitha RajeevCorresponding
National University of Singapore, National University Health System
- YLYuek Ling Chai
National University of Singapore, National University Health System
- LPLuting Poh
National University of Singapore, National University Health System
- SSSharmelee Selvaraji
National University of Singapore, National University Health System
- DYDavid Y. Fann
National University of Singapore
Topics & keywords
- Medicine
- Neuroscience
- Cerebral blood flow
- Disease
- Neurology
- Cognition
- Cerebral hypoperfusion
- Etiology
- Good health and well-being