A pangenome reference of 36 Chinese populations
Fudan University · ShanghaiTech University · +21 more institutions
Abstract
Abstract Human genomics is witnessing an ongoing paradigm shift from a single reference sequence to a pangenome form, but populations of Asian ancestry are underrepresented. Here we present data from the first phase of the Chinese Pangenome Consortium, including a collection of 116 high-quality and haplotype-phased de novo assemblies based on 58 core samples representing 36 minority Chinese ethnic groups. With an average 30.65× high-fidelity long-read sequence coverage, an average contiguity N50 of more than 35.63 megabases and an average total size of 3.01 gigabases, the CPC core assemblies add 189 million base pairs of euchromatic polymorphic sequences and 1,367 protein-coding gene duplications to GRCh38. We…
Citation impact
- FWCI
- 26.44
- Percentile
- 100%
- References
- 76
Authors
42- YGYang Gao
Fudan University, ShanghaiTech University, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences
- XYXiaofei Yang
First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University
- HCHao Chen
Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences
- XTXinjiang Tan
Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences
- ZYZhaoqing Yang
Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University
Topics & keywords
- Haplotype
- Genetics
- Biology
- Coding region
- Contiguity
- Genomics
- Computational biology
- Gene
Funding
- SSanofi
- NNNational Natural Science Foundation of ChinaAwards: 32030020, 2018YFC1311500, 31900418, 32125009, 32288101, 82170805, 32070663, 2017SHZDZX01, 62172325, 32270665, 31961130380, 81970679
- CAChinese Academy of SciencesAwards: 2017SHZDZX01, XDB38000000, 2018YFC1311500
- YKYunnan Key Research and Development Program