Chronic inflammation and the hallmarks of aging
Buck Institute for Research on Aging · University Health Network · +6 more institutions
Abstract
BACKGROUND: Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, the low-grade chronic inflammation during aging, without overt infection, is defined as "inflammaging," which is associated with increased morbidity and mortality in the aging population. Emerging evidence suggests a bidirectional and cyclical relationship between chronic inflammation and the development of age-related conditions, such as cardiovascular diseases, neurodegeneration, cancer, and frailty. How the crosstalk between chronic inflammation and other hallmarks of aging underlies biological mechanisms of aging and age-related disease is thus of particular…
Citation impact
- FWCI
- 76.30
- Percentile
- 100%
- References
- 453
Authors
6- JJJordan J. Baechle
Buck Institute for Research on Aging
- NCNan Chen
University Health Network, University of Toronto, Toronto General Hospital
- PMPriya Makhijani
Buck Institute for Research on Aging, University of Toronto
- SWShawn Winer
University of Toronto
- DFDavid FurmanCorresponding
Buck Institute for Research on Aging, Consejo Nacional de Investigaciones Científicas y Técnicas, Austral University, Stanford University
Topics & keywords
- Inflammation
- Neurodegeneration
- Medicine
- Disease
- Immunosenescence
- Dementia
- Healthy aging
- Immunology
- Good health and well-being