Physiology of sedentary behavior

Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or reclining posture. Evidence relevant to understanding the physiology of SB can be derived from studies employing several experimental models: bed rest, immobilization, reduced step count, and reducing/interrupting prolonged SB. We examine the relevant physiological evidence relating to body weight and energy balance, intermediary metabolism, cardiovascular and respiratory systems, the musculoskeletal system, the central nervous system, and immunity and inflammatory responses. Excessive and prolonged SB can lead to insulin resistance, vascular dysfunction, shift in substrate use toward carbohydrate oxidation, shift in…

• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Awards: 2015/26937-4, 2015/, 2017/13552-2, 2018/19418-9
• NI
  National Institutes of Health

  Award: R01DK123334
• AM
  Anschutz Medical Campus, University of Colorado
• MR
  Medical Research Council
• NH
  National Health and Medical Research Council

  Awards: 1057608, #1057608, 1142685, #1142685
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases
• DO
  Division of Diabetes, Endocrinology, and Metabolic Diseases

  Award: R01DK123334