reviewInternational Journal of Molecular SciencesJun 18, 2023GOLD OA

Hyaluronic Acid: A Powerful Biomolecule with Wide-Ranging Applications—A Comprehensive Review

University of Salento · University of Calabria · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Hyaluronic acid (HA) is a glycosaminoglycan widely distributed in the human body, especially in body fluids and the extracellular matrix of tissues. It plays a crucial role not only in maintaining tissue hydration but also in cellular processes such as proliferation, differentiation, and the inflammatory response. HA has demonstrated its efficacy as a powerful bioactive molecule not only for skin antiaging but also in atherosclerosis, cancer, and other pathological conditions. Due to its biocompatibility, biodegradability, non-toxicity, and non-immunogenicity, several HA-based biomedical products have been developed. There is an increasing focus on optimizing HA production processes to achieve high-quality,…

Citation impact

211
total citations
FWCI
41.31
Percentile
100%
References
155
Citations per year

Authors

7

Topics & keywords

Keywords
  • Hyaluronic acid
  • Biocompatibility
  • Extracellular matrix
  • Glycosaminoglycan
  • Biomolecule
  • Biomedicine
  • Chemistry
  • Immunogenicity
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