Physiology and diseases of tissue-resident macrophages

Embryo-derived tissue-resident macrophages are the first representatives of the haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages originate from early yolk sac progenitors and are specified into tissue-specific subsets during organogenesis-establishing stable spatial and functional relationships with specialized tissue cells-and persist in adults. Resident macrophages are an integral part of tissues together with specialized cells: for instance, microglia reside with neurons in brain, osteoclasts reside with osteoblasts in bone, and fat-associated macrophages reside with white adipocytes in adipose tissue. This ancillary cell type, which is developmentally and functionally…

• MS
  Memorial Sloan-Kettering Cancer Center

  Award: P30CA008748
• NI
  National Institutes of Health

  Award: P30CA008748
• NH
  National Heart, Lung, and Blood Institute
• NC
  National Cancer Institute

  Award: P30CA008748
• NI
  National Institute of Allergy and Infectious Diseases

  Awards: 1R01AI130345, P30CA008748
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Award: P30CA008748