Tryptophan metabolism in health and disease
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases · First Affiliated Hospital Zhejiang University · +1 more institution
Abstract
Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function. Emerging evidence supports an intimate relationship between Trp metabolism disorder and diseases. The levels or ratios of Trp metabolites are significantly associated with many clinical features. Additionally, studies have shown that disease progression can be controlled by modulating Trp metabolism. Indoleamine-2,3-dioxygenase, Trp-2,3-dioxygenase, kynurenine-3-monooxygenase, and Trp hydroxylase are the rate-limiting…
Citation impact
- FWCI
- 77.05
- Percentile
- 100%
- References
- 195
Authors
11- XCXue Chen
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital Zhejiang University, Zhejiang University
- GLGanglei Li
First Affiliated Hospital Zhejiang University, Zhejiang University
- QZQiuxian Zheng
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital Zhejiang University, Zhejiang University
- XGXinyu Gu
Zhejiang University, First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
- QSQingmiao Shi
First Affiliated Hospital Zhejiang University, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, Zhejiang University
Topics & keywords
- Kynurenine
- Tryptophan Metabolism
- Kynurenine pathway
- Indoleamine 2,3-dioxygenase
- Metabolism
- Tryptophan
- Biology
- Dioxygenase
- Good health and well-being