FSP1: a key regulator of ferroptosis
Central South University · Xiangya Hospital Central South University
Abstract
Ferroptosis suppressor protein 1 (FSP1) is one of the main regulatory molecules of ferroptosis. FSP1 functions through the FSP1-coenzyme Q10 (CoQ10)-NAD(P)H axis and the vitamin K redox cycle. FSP1 is regulated by upstream factors, including transcription factors and noncoding RNA (ncRNA), and is subject to epigenetic modifications, which affect the progress of FSP1-related diseases. FSP1 is closely associated with the poor prognosis of malignant tumors and plays an important role in disease treatment. This review aims to provide a comprehensive understanding of the role of FSP1 in ferroptosis regulation by summarizing regulatory pathways, possible mechanisms involving FSP1, and the relationship between FSP1…
Citation impact
- FWCI
- 58.12
- Percentile
- 100%
- References
- 107
Authors
5- WLWentao Li
Central South University, Xiangya Hospital Central South University
- LLLin Liang
Central South University
- SLSiyi Liu
Central South University
- HYHong YiCorresponding
Central South University, Xiangya Hospital Central South University
- YZYanhong ZhouCorresponding
Central South University, Xiangya Hospital Central South University
Topics & keywords
- Regulator
- Epigenetics
- microRNA
- Transcription factor
- Biology
- Transcriptional regulation
- Disease
- Genetics