Spinal cord injury: molecular mechanisms and therapeutic interventions

Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system. In the past few decades, researchers have attempted to completely elucidate the pathological mechanism of SCI and identify effective strategies to promote axon regeneration and neural circuit remodeling, but the results have not been ideal. Recently, new pathological mechanisms of SCI, especially the interactions between immune and neural cell responses, have been revealed by single-cell sequencing and spatial transcriptome analysis. With the development of bioactive…

• NN
  National Natural Science Foundation of China

  Awards: 82202351, 81873994, 82030035, 82225027, 2016YFA0100800, 81820108013, 31620103904, 82202702, 31727801, No. 81330030, 81901902, 81330030
• NK
  National Key Research and Development Program of China

  Awards: 82202702, No. 2016YFA0100800, 2016YFA0100800, 82225027, 2021YFA1101301