reviewDiseasesJun 25, 2023GOLD OA

WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective

KRKakarla RamakrishnaLVLakshmi Vineela NallaNDNaresh DumalaKVKojja VenkateswarluMKMatte Kasi Viswanadh

Koneru Lakshmaiah Education Foundation · Indian Institute of Technology BHU · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood. The canonical pathway of WβC signaling is essential for neurogenesis, cell proliferation, and neurogenesis, whereas the noncanonical pathway (WNT/Ca2+ and WNT/PCP) is responsible for cell polarity, calcium maintenance, and cell migration. Abnormal regulation of WβC signaling is involved in the pathogenesis of several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and spinal muscular atrophy (SMA). Hence, the…

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191
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37.33
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100%
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Authors

13

Topics & keywords

Topics
Keywords
  • Wnt signaling pathway
  • Neurogenesis
  • Amyotrophic lateral sclerosis
  • Neuroscience
  • Biology
  • Signal transduction
  • Spinal muscular atrophy
  • Disease
UN Sustainable Development Goals
  • Good health and well-being
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