Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have been extensively researched since the landmark report by Morpurgo (1897) of "work-induced hypertrophy" in dogs that were treadmill trained. Much of the preclinical rodent and human resistance training research to date supports that involved mechanisms include enhanced mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling, an expansion in translational capacity through ribosome biogenesis, increased satellite cell abundance and myonuclear accretion, and postexercise elevations in muscle protein synthesis rates. However, several lines of past and emerging evidence suggest that additional mechanisms that feed into…

• FD
  Fundação de Amparo à Pesquisa do Estado de São Paulo

  Award: 2020/13613-4
• CN
  Conselho Nacional de Desenvolvimento Científico e Tecnológico

  Award: 311387/2021-7
• CI
  Canadian Institutes of Health Research
• JS
  Japan Society for the Promotion of Science

  Award: 22H03465
• NI
  National Institute on Aging

  Awards: U01AG055137, AG069909
• NI
  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  Awards: AR079220, AR072735, AR078430, R01AR074932
• DO
  Division of Diabetes, Endocrinology, and Metabolic Diseases

  Award: DK119619