Immune regulation through tryptophan metabolism
Inje University · Ulsan College · +2 more institutions
Abstract
Amino acids are fundamental units of molecular components that are essential for sustaining life; however, their metabolism is closely interconnected to the control systems of cell function. Tryptophan (Trp) is an essential amino acid catabolized by complex metabolic pathways. Several of the resulting Trp metabolites are bioactive and play central roles in physiology and pathophysiology. Additionally, various physiological functions of Trp metabolites are mutually regulated by the gut microbiota and intestine to coordinately maintain intestinal homeostasis and symbiosis under steady state conditions and during the immune response to pathogens and xenotoxins. Cancer and inflammatory diseases are associated with…
Citation impact
- FWCI
- 28.90
- Percentile
- 100%
- References
- 114
Authors
2Topics & keywords
- Tryptophan Metabolism
- Immune system
- Metabolism
- Tryptophan
- Biology
- Immunology
- Biochemistry
- Amino acid