Diabetic Foot Ulcers

Importance: Approximately 18.6 million people worldwide are affected by a diabetic foot ulcer each year, including 1.6 million people in the United States. These ulcers precede 80% of lower extremity amputations among people diagnosed with diabetes and are associated with an increased risk of death. Observations: Neurological, vascular, and biomechanical factors contribute to diabetic foot ulceration. Approximately 50% to 60% of ulcers become infected, and about 20% of moderate to severe infections lead to lower extremity amputations. The 5-year mortality rate for individuals with a diabetic foot ulcer is approximately 30%, exceeding 70% for those with a major amputation. The mortality rate for people with…

• NS
  National Science Foundation

  Award: 2052578
• NI
  National Institutes of Health

  Award: 1R01124789-01A1
• NI
  National Institute of Diabetes and Digestive and Kidney Diseases

  Awards: 1R01124789, 1K23DK122126, 1R01124789-01A1