SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity

Abstract Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1,2 . Dendritic cells (DCs), especially type-1 conventional DCs (cDC1s), mediate T cell priming and therapeutic efficacy against tumours 3 . DC functions are orchestrated by pattern recognition receptors 3–5 , although other signals involved remain incompletely defined. Nutrients are emerging mediators of adaptive immunity 6–8 , but whether nutrients affect DC function or communication between innate and adaptive immune cells is largely unresolved. Here we establish glutamine as an intercellular metabolic checkpoint that dictates tumour–cDC1 crosstalk and licenses cDC1 function in…

• AL
  American Lebanese Syrian Associated Charities
• NI
  National Institutes of Health

  Awards: AI150514, AI131703, AI105887, AI140761, CA253188, AI150241