CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications
Northwest University · Ministry of Education of the People's Republic of China · +4 more institutions
Abstract
Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or epigenetic changes, and is the biggest challenge around the world. Cytokines, including chemokines, exhibit expression changes and disorders in all human cancers. These cytokine abnormalities can disrupt homeostasis and immune function, and make outstanding contributions to various stages of cancer development such as invasion, metastasis, and angiogenesis. Chemokines are a superfamily of small molecule chemoattractive cytokines that mediate a variety of cellular functions. Importantly, the interactions of chemokine members CXCL12 and its receptors CXCR4 and CXCR7 have a broad impact on tumor cell proliferation, survival,…
Citation impact
- FWCI
- 44.39
- Percentile
- 100%
- References
- 199
Authors
13- YYYaru YangCorresponding
Northwest University, Ministry of Education of the People's Republic of China
- JLJiayan Li
Northwest University, Ministry of Education of the People's Republic of China
- WLWangrui Lei
Ministry of Education of the People's Republic of China, Northwest University
- HWHaiying Wang
Ministry of Education of the People's Republic of China, Northwest University
- YNYunfeng Ni
Tang Du Hospital, Northwest University, Ministry of Education of the People's Republic of China
Topics & keywords
- Metastasis
- Angiogenesis
- Cancer
- Tumor microenvironment
- Cancer research
- Biology
- Chemokine
- Prostate cancer
- Good health and well-being