articleNature MedicineJul 1, 2023HYBRID OA

A multi-ancestry polygenic risk score improves risk prediction for coronary artery disease

APAniruddh P. PatelMWMinxian WangYRYunfeng RuanSKSatoshi KoyamaSLShoa L. Clarke

Broad Institute · Harvard University · +15 more institutions

PubMed
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Abstract

Abstract Identification of individuals at highest risk of coronary artery disease (CAD)—ideally before onset—remains an important public health need. Prior studies have developed genome-wide polygenic scores to enable risk stratification, reflecting the substantial inherited component to CAD risk. Here we develop a new and significantly improved polygenic score for CAD, termed GPS Mult , that incorporates genome-wide association data across five ancestries for CAD (>269,000 cases and >1,178,000 controls) and ten CAD risk factors. GPS Mult strongly associated with prevalent CAD (odds ratio per standard deviation 2.14, 95% confidence interval 2.10–2.19, P < 0.001) in UK Biobank participants of European…

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Topics & keywords

Topics
Keywords
  • Odds ratio
  • Confidence interval
  • Coronary artery disease
  • Medicine
  • Framingham Risk Score
  • Genome-wide association study
  • Hazard ratio
  • Polygenic risk score
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