MOF-On-MOF Dual Enzyme-Mimic Nanozyme with Enhanced Cascade Catalysis for Colorimetric/Chemiluminescent Dual-Mode Aptasensing

Chai, Huining; Yu, Kun; Zhao, Yiming; Zhang, Ziyan; Wang, Shasha; Huang, Chaonan; Zhang, Xueji; Zhang, Guangyao

doi:10.1021/acs.analchem.3c01905

articleAnalytical ChemistryJul 10, 2023Closed access

MOF-On-MOF Dual Enzyme-Mimic Nanozyme with Enhanced Cascade Catalysis for Colorimetric/Chemiluminescent Dual-Mode Aptasensing

HCHuining Chai KYKun Yu YZYiming Zhao ZZZiyan Zhang SWShasha Wang

Qingdao University · Qingdao University of Technology · +1 more institution

PubMed

Indexed incrossrefpubmed

Abstract

A novel metal–organic framework (MOF)-on-MOF dual enzyme-mimic nanozyme was designed as enhanced cascade signal amplification for the colorimetric and chemiluminescent (CL) dual-mode aptasensing. The MOF-on-MOF hybrid is composed of MOF-818 with catechol oxidase-like activity and iron porphyrin MOF [PMOF(Fe)] with peroxidase-like activity, called MOF-818@PMOF(Fe). MOF-818 can catalyze the 3,5-di-tert-butylcatechol substrate and produce H2O2 in situ. Subsequently, PMOF(Fe) catalyzes H2O2 to produce reactive oxygen species, which oxidize 3,3′,5,5′-tetramethylbenzidine or luminol to produce color or luminescence. Thanks to the nano-proximity effect and the confinement effect, the efficiency of the biomimetic…

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Topics

Keywords

Chemistry
Chemiluminescence
Luminol
Combinatorial chemistry
Metal-organic framework
Artificial enzyme
Porphyrin
Catechol

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