Role of neuroinflammation in neurodegeneration development

Studies in neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis, Huntington's disease, and so on, have suggested that inflammation is not only a result of neurodegeneration but also a crucial player in this process. Protein aggregates which are very common pathological phenomenon in neurodegeneration can induce neuroinflammation which further aggravates protein aggregation and neurodegeneration. Actually, inflammation even happens earlier than protein aggregation. Neuroinflammation induced by genetic variations in CNS cells or by peripheral immune cells may induce protein deposition in some susceptible population. Numerous signaling pathways and a…

• NN
  National Natural Science Foundation of China

  Awards: 82101443, 81773265, No. 81773265
• NS
  Natural Science Foundation of Shaanxi Province

  Award: 2023-JC-YB-160
• FR
  Fundamental Research Funds for the Central Universities

  Award: GK202202006
• NS
  Natural Science Basic Research Program of Shaanxi Province