Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer’s disease

Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular injuries in cerebral large and small vessels and is a key driver of age-related cognitive decline. Severe VCID includes post-stroke dementia, subcortical ischemic vascular dementia, multi-infarct dementia, and mixed dementia. While VCID is acknowledged as the second most common form of dementia after Alzheimer's disease (AD) accounting for 20% of dementia cases, VCID and AD frequently coexist. In VCID, cerebral small vessel disease (cSVD) often affects arterioles, capillaries, and venules, where arteriolosclerosis and cerebral amyloid angiopathy (CAA) are major pathologies. White matter hyperintensities, recent small subcortical…

• FD
  Florida Department of Health
• CA
  Cure Alzheimer's Fund
• NI
  National Institutes of Health

  Awards: RF1AG057181, RF1AG071226, RF1AG068034, U19AG069701