Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism
Central South University · Hunan Entry-Exit Inspection and Quarantine Bureau · +1 more institution
Abstract
ABSTRACT: Long-chain acyl-coenzyme A (CoA) synthase 4 (ACSL4) is an enzyme that esterifies CoA into specific polyunsaturated fatty acids, such as arachidonic acid and adrenic acid. Based on accumulated evidence, the ACSL4-catalyzed biosynthesis of arachidonoyl-CoA contributes to the execution of ferroptosis by triggering phospholipid peroxidation. Ferroptosis is a type of programmed cell death caused by iron-dependent peroxidation of lipids; ACSL4 and glutathione peroxidase 4 positively and negatively regulate ferroptosis, respectively. In addition, ACSL4 is an essential regulator of fatty acid (FA) metabolism. ACSL4 remodels the phospholipid composition of cell membranes, regulates steroidogenesis, and…
Citation impact
- FWCI
- 67.78
- Percentile
- 100%
- References
- 182
Authors
7- KDKaiyue Ding
Central South University, Hunan Entry-Exit Inspection and Quarantine Bureau, Second Xiangya Hospital of Central South University
- CLChongbin Liu
Central South University, Hunan Entry-Exit Inspection and Quarantine Bureau, Second Xiangya Hospital of Central South University
- LLLi LiCorresponding
Central South University, Hunan Entry-Exit Inspection and Quarantine Bureau, Second Xiangya Hospital of Central South University
- MYMing Yang
Central South University, Hunan Entry-Exit Inspection and Quarantine Bureau, Second Xiangya Hospital of Central South University
- NJNa Jiang
Central South University, Hunan Entry-Exit Inspection and Quarantine Bureau, Second Xiangya Hospital of Central South University
Topics & keywords
- Biochemistry
- Arachidonic acid
- Metabolism
- Polyunsaturated fatty acid
- Lipid peroxidation
- Fatty acid
- Lipid metabolism
- Biology
- Good health and well-being