CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

Horie, Kanta; Salvadó, Gemma; Barthélemy, Nicolas R.; Janelidze, Shorena; Li, Yan; He, Yingxin; Saef, Benjamin; Chen, Charles D.; Jiang, Hong; Strandberg, Olof; Binette, Alexa Pichet; Palmqvist, Sebastian; Sato, Chihiro; Sachdev, Pallavi; Koyama, Akihiko; Gordon, Brian A.; Benzinger, Tammie L.S.; Holtzman, David M.; Morris, John C.; Mattsson, Niklas; Stomrud, Erik; Ossenkoppele, Rik; Schindler, Suzanne E.; Hansson, Oskar; Bateman, Randall J.

doi:10.1038/s41591-023-02443-z

articleNature MedicineJul 13, 2023HYBRID OA

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease

KHKanta Horie GSGemma Salvadó NRNicolas R. Barthélemy SJShorena Janelidze YLYan Li

Washington University in St. Louis · Eisai (United States) · +6 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract Aggregated insoluble tau is one of two defining features of Alzheimer’s disease. Because clinical symptoms are strongly correlated with tau aggregates, drug development and clinical diagnosis need cost-effective and accessible specific fluid biomarkers of tau aggregates; however, recent studies suggest that the fluid biomarkers currently available cannot specifically track tau aggregates. We show that the microtubule-binding region (MTBR) of tau containing the residue 243 (MTBR-tau243) is a new cerebrospinal fluid (CSF) biomarker specific for insoluble tau aggregates and compared it to multiple other phosphorylated tau measures (p-tau181, p-tau205, p-tau217 and p-tau231) in two independent cohorts…

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Topics & keywords

Topics

Keywords

Biomarker
Tau pathology
Tangle
Cerebrospinal fluid
Binding potential
Disease
Positron emission tomography
Tau protein

UN Sustainable Development Goals

Good health and well-being

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