A distinct stimulatory cDC1 subpopulation amplifies CD8+ T cell responses in tumors for protective anti-cancer immunity
Technical University of Munich · Imperial College London · +5 more institutions
Abstract
Type 1 conventional dendritic cells (cDC1) can support T cell responses within tumors but whether this determines protective versus ineffective anti-cancer immunity is poorly understood. Here, we use imaging-based deep learning to identify intratumoral cDC1-CD8+ T cell clustering as a unique feature of protective anti-cancer immunity. These clusters form selectively in stromal tumor regions and constitute niches in which cDC1 activate TCF1+ stem-like CD8+ T cells. We identify a distinct population of immunostimulatory CCR7neg cDC1 that produce CXCL9 to promote cluster formation and cross-present tumor antigens within these niches, which is required for intratumoral CD8+ T cell differentiation and expansion and…
Citation impact
- FWCI
- 27.95
- Percentile
- 100%
- References
- 85
Authors
23Topics & keywords
- CD8
- Biology
- Cancer
- Stromal cell
- Cancer research
- Cytotoxic T cell
- Immune system
- Population
- Good health and well-being