Molecular mechanisms governing antifungal drug resistance

Abstract Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida , Cryptococcus , and Aspergillus genera. As opportunistic pathogens, these fungi are generally harmless in healthy hosts; however, they can cause significant morbidity and mortality in immunocompromised patients. Despite the profound impact of pathogenic fungi on global human health, the current antifungal armamentarium is limited to only three major classes of drugs, all of which face complications, including host toxicity, unfavourable pharmacokinetics, or limited spectrum of activity. Further exacerbating this issue is the growing prevalence of…

• DO
  Division of Intramural Research, National Institute of Allergy and Infectious Diseases

  Award: R01AI1654661
• CI
  Canadian Institute for Advanced Research
• NI
  National Institutes of Health

  Awards: R01AI162789, NIAID R01
• CI
  Canadian Institutes of Health Research

  Award: FDN-154288
• NI
  National Institute of Allergy and Infectious Diseases

  Award: R01AI162789