articleNatureJul 19, 2023HYBRID OA

A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection

DGDanillo G. AugustoLDLawton D. MurdoloDSDemetra S.M. ChatzileontiadouJJJoseph J. SabatinoTYTasneem Yusufali

University of North Carolina at Charlotte · University of California, San Francisco · +10 more institutions

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Abstract

. Although most global efforts have focused on severe illness in COVID-19, examining asymptomatic infection provides a unique opportunity to consider early immunological features that promote rapid viral clearance. Here, postulating that variation in the human leukocyte antigen (HLA) loci may underly processes mediating asymptomatic infection, we enrolled 29,947 individuals, for whom high-resolution HLA genotyping data were available, in a smartphone-based study designed to track COVID-19 symptoms and outcomes. Our discovery cohort (n = 1,428) comprised unvaccinated individuals who reported a positive test result for SARS-CoV-2. We tested for association of five HLA loci with disease course and identified a…

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Topics & keywords

Topics
Keywords
  • Asymptomatic
  • Immunology
  • Human leukocyte antigen
  • Allele
  • Biology
  • Genotyping
  • Disease
  • Genotype
UN Sustainable Development Goals
  • Good health and well-being
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