Dimensionality Engineering of Single-Atom Nanozyme for Efficient Peroxidase-Mimicking
Chinese Academy of Sciences · Changchun Institute of Applied Chemistry · +2 more institutions
Abstract
In nature, enzymatic reactions occur in well-functioning catalytic pockets, where substrates bind and react by properly arranging the catalytic sites and amino acids in a three-dimensional (3D) space. Single-atom nanozymes (SAzymes) are a new type of nanozymes with active sites similar to those of natural metalloenzymes. However, the catalytic centers in current SAzymes are two-dimensional (2D) architectures and the lack of collaborative substrate-binding features limits their catalytic activity. Herein, we report a dimensionality engineering strategy to convert conventional 2D Fe–N-4 centers into 3D structures by integrating oxidized sulfur functionalities onto the carbon plane. Our results suggest that…
Citation impact
- FWCI
- 20.54
- Percentile
- 100%
- References
- 41
Authors
6- GLGuangming Li
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- HLHao Liu
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- THTianding Hu
Kunming University of Science and Technology
- FPFang Pu
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- JRJinsong RenCorresponding
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Chemistry
- Catalysis
- Curse of dimensionality
- Substrate (aquarium)
- Combinatorial chemistry
- Rational design
- Active site
- Nanotechnology