Autophagy mediates an amplification loop during ferroptosis
VA Palo Alto Health Care System · University of Ulsan · +5 more institutions
Abstract
Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is different from apoptosis, necrosis, autophagy, and other forms of cell death. However, accumulating evidence has revealed a link between autophagy and ferroptosis at the molecular level and has suggested that autophagy is involved in regulating the accumulation of iron-dependent lipid peroxidation and ROS during ferroptosis. Understanding the roles and pathophysiological processes of autophagy during ferroptosis may provide effective strategies for the…
Citation impact
- FWCI
- 46.60
- Percentile
- 100%
- References
- 124
Authors
6- SLSeunghee LeeCorresponding
VA Palo Alto Health Care System, University of Ulsan, Korea Research Institute of Bioscience and Biotechnology
- NHNarae Hwang
Brigham and Women's Hospital, Harvard University
- BGByeong Geun Seok
University of Ulsan
- SLSangguk Lee
VA Palo Alto Health Care System, University of Ulsan, Korea Research Institute of Bioscience and Biotechnology
- SLSeon‐Jin Lee
VA Palo Alto Health Care System, University of Ulsan, Korea Research Institute of Bioscience and Biotechnology
Topics & keywords
- Autophagy
- GPX4
- Programmed cell death
- Cell biology
- Reactive oxygen species
- Apoptosis
- Biology
- Lipid peroxidation
- Good health and well-being