articleNature CommunicationsJul 26, 2023GOLD OA

Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease

AGAlba Garrido-TrigoAMA M CorralizaMVMarisol VenyIDIsabella DottiEMElisa Melón-Ardanaz

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · Consorci Institut D'Investigacions Biomediques August Pi I Sunyer · +11 more institutions

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Abstract

Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with perplexing heterogeneity in disease manifestation and response to treatment. While the molecular basis for this heterogeneity remains uncharacterized, single-cell technologies allow us to explore the transcriptional states within tissues at an unprecedented resolution which could further understanding of these complex diseases. Here, we apply single-cell RNA-sequencing to human inflamed intestine and show that the largest differences among patients are present within the myeloid compartment including macrophages and neutrophils. Using spatial transcriptomics in human tissue at single-cell resolution (CosMx Spatial…

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Topics & keywords

Topics
Keywords
  • Single-cell analysis
  • Transcriptome
  • Biology
  • Macrophage
  • Cell
  • Myeloid
  • Inflammatory bowel disease
  • RNA
UN Sustainable Development Goals
  • Good health and well-being
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