Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the conversion from mechanical signals to biochemical signals regarding cell activities and metabolism. Typical mechanical cues in organisms include hydrostatic pressure, fluid shear stress, tensile force, extracellular matrix stiffness or tissue elasticity, and extracellular fluid viscosity. Mechanotransduction has been expected to trigger multiple biological processes, such as embryonic development, tissue repair and regeneration. However, prolonged excessive mechanical stimulation can result in pathological processes, such as multi-organ fibrosis, tumorigenesis, and cancer immunotherapy resistance. Although the…

• NN
  National Natural Science Foundation of China

  Award: 81873601
• SU
  Sichuan University

  Award: ZYGD18011
• NI
  National Institutes of Health
• WC
  West China Hospital, Sichuan University

  Awards: ZYGD18011, 1.3.5 project, 1.3.5
• UN
  U.S. National Library of Medicine