Metal-Based Photosensitizers as Inducers of Regulated Cell Death Mechanisms

Over the last few decades, various forms of regulated cell death (RCD) have been discovered and were found to improve cancer treatment. Although there are several reviews on RCD induced by photodynamic therapy (PDT), a comprehensive summary covering metal-based photosensitizers (PSs) as RCD inducers has not yet been presented. In this review, we systematically summarize the works on metal-based PSs that induce different types of RCD, including ferroptosis, immunogenic cell death (ICD), and pyroptosis. The characteristics and mechanisms of each RCD are explained. At the end of each section, a summary of the reported commonalities between different metal-based PSs inducing the same RCD is emphasized, and future…

• AN
  Agence Nationale de la Recherche

  Awards: ANR-10-IDEX-, ANR-10-IDEX-0001-02 PSL, ANR-10-IDEX-0001-02, ANR-10-IDEX-0001, 10-IDEX-0001-02 PSL, 10-IDEX-0001-02, ANR-10-IDEX, ANR-10, IDEX-0001-02
• CS
  China Scholarship Council
• HE
  H2020 European Research Council

  Award: GA 681679