Guidelines for performing Mendelian randomization investigations: update for summer 2023

Burgess, Stephen; Smith, George Davey; Davies, Neil M; Dudbridge, Frank; Gill, Dipender; Glymour, M. Maria; Hartwig, Fernando Pires; Kutalik, Zoltán; Holmes, Michael V.; Minelli, Cosetta; Morrison, Jean; Pan, Wei; Relton, Caroline L.; Τheodoratou, Evropi

doi:10.12688/wellcomeopenres.15555.3

preprintWellcome Open ResearchAug 4, 2023GOLD OA

Guidelines for performing Mendelian randomization investigations: update for summer 2023

SBStephen Burgess GDGeorge Davey Smith NMNeil M Davies FDFrank Dudbridge DGDipender Gill

University of Cambridge · Erasmus MC · +20 more institutions

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Abstract

This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into ten sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust statistical methods and one on other approaches), extensions and additional analyses, data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be…

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686

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Topics & keywords

Topics

Keywords

Mendelian randomization
Scope (computer science)
Harmonization
Presentation (obstetrics)
Computer science
Psychology
Data science
Medicine

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