articleJournal of NanobiotechnologyAug 4, 2023GOLD OA

Anti-glioma effect of ginseng-derived exosomes-like nanoparticles by active blood–brain-barrier penetration and tumor microenvironment modulation

JKJisu KimYZYing ZhuSCSunhui ChenDWDongdong WangSZShuya Zhang

Fudan University · Shanghai Medical College of Fudan University · +5 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Inhibition of tumor growth and normalization of immune responses in the tumor microenvironment (TME) are critical issues for improving cancer therapy. However, in the treatment of glioma, effective nanomedicine has limited access to the brain because of the blood-brain barrier (BBB). Previously, we demonstrated nano-sized ginseng-derived exosome-like nanoparticles (GENs) consisting of phospholipids including various bioactive components, and evaluated anti-tumor immune responses in T cells and Tregs to inhibit tumor progression. It was found that the enhanced targeting ability of GENs to the BBB and glioma induced a significant therapeutic effect and exhibited strong efficacy in recruiting M1 macrophage…

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233
total citations
FWCI
34.33
Percentile
100%
References
51
Citations per year

Authors

10

Topics & keywords

Topics
Keywords
  • Glioma
  • Tumor microenvironment
  • Exosome
  • Blood–brain barrier
  • Ginseng
  • Immune system
  • Microvesicles
  • Cancer research
UN Sustainable Development Goals
  • Good health and well-being
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