articleProceedings of the National Academy of SciencesAug 7, 2023GREEN OA

The liquid-to-solid transition of FUS is promoted by the condensate surface

YSYi ShenACAnqi ChenWWWenyun WangYSYinan ShenFSFrancesco Simone Ruggeri

The University of Sydney · Harvard University · +6 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

A wide range of macromolecules can undergo phase separation, forming biomolecular condensates in living cells. These membraneless organelles are typically highly dynamic, formed reversibly, and carry out essential functions in biological systems. Crucially, however, a further liquid-to-solid transition of the condensates can lead to irreversible pathological aggregation and cellular dysfunction associated with the onset and development of neurodegenerative diseases. Despite the importance of this liquid-to-solid transition of proteins, the mechanism by which it is initiated in normally functional condensates is unknown. Here we show, by measuring the changes in structure, dynamics, and mechanics in time and…

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180
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Authors

15

Topics & keywords

Topics
Keywords
  • Chemical physics
  • Rheology
  • Phase transition
  • Materials science
  • Phase (matter)
  • Speckle pattern
  • Chemistry
  • Nanotechnology
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