Universal DNA methylation age across mammalian tissues
Fleet Science Center · University of California, Los Angeles · +101 more institutions
Abstract
Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb…
Citation impact
- FWCI
- 53.60
- Percentile
- 100%
- References
- 107
Authors
188- ATAke T. Lu
Fleet Science Center, University of California, Los Angeles, Altos Labs
- ZFZhe Fei
University of California, Riverside, University of California, Los Angeles
- AHAmin Haghani
Fleet Science Center, University of California, Los Angeles, Altos Labs
- TRTodd R. Robeck
SeaWorld Entertainment
- JAJoseph A. Zoller
University of California, Los Angeles
Topics & keywords
- DNA methylation
- Biology
- Epigenetics
- Methylation
- Genomic imprinting
- Genetics
- Gene
- Developmental biology
- Good health and well-being
Funding
- UDU.S. Department of Health and Human ServicesAwards: HHSN268201600004C, HHSN268201600003C, HHSN268201500001I, HHSN268201600001C, HHSN268201600002C, HHSN268201600018C
- PGPaul G. Allen Family Foundation
- NGNational Geographic Society
- OPOpen Philanthropy Project
- PGPaul G. Allen Frontiers Group
- CRCancer Research UKAward: 20412
- SRSight Research UKAwards: NE/X001423/1, NE/R011397/1
- DODepartment of Science and Technology, Ministry of Science and Technology, IndiaAward: 64756
- NINational Institutes of HealthAwards: HHSN268201600018C, HHSN268201600003C, HHSN268201600004C, HHSN268201600001C, N01-HC-25195, HHSN268201600002C, HHSN268201500001I
- NENatural Environment Research CouncilAwards: NE/X001423/1, NE/R011397/1
- NINational Institute on AgingAwards: N01-HC-25195, HHSN268201600001C, 1U01AG060908 – 01
- NHNational Heart, Lung, and Blood InstituteAwards: HHSN268201600018C, HHSN268201600001C, HHSN268201600002C, HHSN268201600003C and HHSN268201600004C, HHSN268201600018C, HHSN268201500001I, HHSN268201600004C, HHSN268201600001C, N01-HC-25195 and HHSN268201500001I, N01-HC-25195, HHSN268201600003C, HHSN268201600002C
- CFCenter for Information Technology
- JCJonsson Comprehensive Cancer Center
- NDNHLBI Division of Intramural Research