articleNature ImmunologyAug 10, 2023HYBRID OA

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets

JHJing Hua ZhaoDSDavid StaceyNENiclas ErikssonEMErin Macdonald-DunlopÅKÅsa K. Hedman

University of Cambridge · University of South Australia · +29 more institutions

PubMed
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Abstract

Circulating proteins have important functions in inflammation and a broad range of diseases. To identify genetic influences on inflammation-related proteins, we conducted a genome-wide protein quantitative trait locus (pQTL) study of 91 plasma proteins measured using the Olink Target platform in 14,824 participants. We identified 180 pQTLs (59 cis, 121 trans). Integration of pQTL data with eQTL and disease genome-wide association studies provided insight into pathogenesis, implicating lymphotoxin-α in multiple sclerosis. Using Mendelian randomization (MR) to assess causality in disease etiology, we identified both shared and distinct effects of specific proteins across immune-mediated diseases, including…

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Topics & keywords

Topics
Keywords
  • Immune system
  • Disease
  • Immunology
  • Biology
  • Inflammation
  • Computational biology
  • Genetics
  • Bioinformatics
UN Sustainable Development Goals
  • Good health and well-being
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