Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

The immune system is coordinated by an intricate network of stimulatory and inhibitory circuits that regulate host responses against endogenous and exogenous insults. Disruption of these safeguard and homeostatic mechanisms can lead to unpredictable inflammatory and autoimmune responses, whereas deficiency of immune stimulatory pathways may orchestrate immunosuppressive programs that contribute to perpetuate chronic infections, but also influence cancer development and progression. Glycans have emerged as essential components of homeostatic circuits, acting as fine-tuners of immunological responses and potential molecular targets for manipulation of immune tolerance and activation in a wide range of pathologic…

• UD
  U.S. Department of Defense
• EC
  European Crohn's and Colitis Organisation
• EC
  European Commission

  Awards: 101093997, 2020., 101071386
• ES
  European Society of Clinical Microbiology and Infectious Diseases
• FP
  Fundação para a Ciência e a Tecnologia
• UA
  U.S. Army Medical Research Acquisition Activity