Injectable, self-healing hydrogel adhesives with firm tissue adhesion and on-demand biodegradation for sutureless wound closure
University of Science and Technology of China · Chinese Academy of Sciences · +2 more institutions
Abstract
Tissue adhesives have garnered extensive interest as alternatives and supplements to sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate biocompatibility, and uncontrolled biodegradation. Here, injectable and biocompatible hydrogel adhesives are developed via catalyst-free o- phthalaldehyde/amine (hydrazide) cross-linking reaction. The hydrogels demonstrate rapid and firm adhesion to various tissues, and an o- phthalaldehyde–mediated tissue adhesion mechanism is established. The hydrogel adhesives show controlled degradation profiles of 6 to 22 weeks in vivo through the incorporation of disulfide bonds into hydrogel network. In liver and blood vessel injury, the hydrogels…
Citation impact
- FWCI
- 110.43
- Percentile
- 100%
- References
- 81
Authors
6- HPHui Ping RenCorresponding
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- ZZZhen ZhangCorresponding
Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- XCXueliang Cheng
Second Affiliated Hospital of Jilin University
- ZZZheng Zou
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
- XCXuesi Chen
University of Science and Technology of China, Chinese Academy of Sciences, Changchun Institute of Applied Chemistry
Topics & keywords
- Self-healing hydrogels
- Cyanoacrylate
- Adhesive
- Fibrin glue
- Wound healing
- Tissue Adhesion
- Biocompatibility
- Adhesion
- Clean water and sanitation