Platelet factors attenuate inflammation and rescue cognition in ageing

. Here we show that platelet factors transfer the benefits of young blood to the ageing brain. Systemic exposure of aged male mice to a fraction of blood plasma from young mice containing platelets decreased neuroinflammation in the hippocampus at the transcriptional and cellular level and ameliorated hippocampal-dependent cognitive impairments. Circulating levels of the platelet-derived chemokine platelet factor 4 (PF4) (also known as CXCL4) were elevated in blood plasma preparations of young mice and humans relative to older individuals. Systemic administration of exogenous PF4 attenuated age-related hippocampal neuroinflammation, elicited synaptic-plasticity-related molecular changes and improved cognition…

• NS
  National Science Foundation
• SF
  Simons Foundation
• LL
  Larry L. Hillblom Foundation
• NI
  National Institutes of Health

  Awards: DK063720, P30 DK063720, SCR_018206
• UO
  University of California, San Francisco

  Award: SCR_018206
• SR
  Stanford Research Computing Center, Stanford University
• NI
  National Institute on Aging

  Awards: AG064823, AG081038, AG077816, AG067740
• NC
  National Cancer Institute