articleEuropean Heart JournalAug 17, 2023GREEN OA

Inflammation in acute myocardial infarction: the good, the bad and the ugly

MMM. MatterFPFrancesco PaneniPLPeter LibbySFStefan FrantzBEBarbara E. Stähli

University of Zurich · University Hospital of Zurich · +6 more institutions

PubMed
Indexed incrossrefdatacitepubmed

Abstract

Convergent experimental and clinical evidence have established the pathophysiological importance of pro-inflammatory pathways in coronary artery disease. Notably, the interest in treating inflammation in patients suffering acute myocardial infarction (AMI) is now expanding from its chronic aspects to the acute setting. Few large outcome trials have proven the benefits of anti-inflammatory therapies on cardiovascular outcomes by targeting the residual inflammatory risk (RIR), i.e. the smouldering ember of low-grade inflammation persisting in the late phase after AMI. However, these studies have also taught us about potential risks of anti-inflammatory therapy after AMI, particularly related to impaired host…

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Topics & keywords

Topics
Keywords
  • Medicine
  • Inflammation
  • Myocardial infarction
  • Intensive care medicine
  • Clinical trial
  • Disease
  • Coronary artery disease
  • Canakinumab
UN Sustainable Development Goals
  • Good health and well-being
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