Hedgehog signaling in tissue homeostasis, cancers and targeted therapies

The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary cilium. HH signaling pathway has important functions in embryonic development and tissue homeostasis. It plays a central role in the regulation of the proliferation and differentiation of adult stem cells. Importantly, it has become increasingly clear that HH signaling pathway is associated with increased cancer prevalence, malignant progression, poor prognosis and even increased mortality. Understanding the integrative nature of HH signaling pathway has opened up the…

• CA
  China Association for Science and Technology

  Award: 2020QNRC001
• NN
  National Natural Science Foundation of China

  Awards: 81800928, 82222015, 2020QNRC001, 82222015, 82171001 and 81800928, 82171001
• SU
  Sichuan University