Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging
Constantine the Philosopher University in Nitra · Slovak University of Technology in Bratislava · +2 more institutions
Abstract
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species (collectively known as ROS/RNS) is termed oxidative eustress or "good stress" and is characterized by low to mild levels of oxidants involved in the regulation of various biochemical transformations such as carboxylation, hydroxylation, peroxidation, or modulation of signal transduction pathways such as Nuclear factor-κB (NF-κB), Mitogen-activated protein kinase (MAPK) cascade, phosphoinositide-3-kinase, nuclear factor erythroid 2-related factor 2 (Nrf2) and other processes. Increased levels of ROS/RNS, generated from both endogenous (mitochondria, NADPH oxidases) and/or exogenous sources (radiation, certain drugs, foods,…
Citation impact
- FWCI
- 331.84
- Percentile
- 100%
- References
- 675
Authors
7Topics & keywords
- Oxidative stress
- Reactive oxygen species
- Reactive nitrogen species
- Chemistry
- Peroxynitrite
- Superoxide dismutase
- Oxidative phosphorylation
- Biochemistry
- Good health and well-being