Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers
University of Oxford · National and Kapodistrian University of Athens · +19 more institutions
Abstract
Obesity is a modifiable cardiovascular risk factor, but adipose tissue (AT) depots in humans are anatomically, histologically, and functionally heterogeneous. For example, visceral AT is a pro-atherogenic secretory AT depot, while subcutaneous AT represents a more classical energy storage depot. Perivascular adipose tissue (PVAT) regulates vascular biology via paracrine cross-talk signals. In this position paper, the state-of-the-art knowledge of various AT depots is reviewed providing a consensus definition of PVAT around the coronary arteries, as the AT surrounding the artery up to a distance from its outer wall equal to the luminal diameter of the artery. Special focus is given to the interactions between…
Citation impact
- FWCI
- 42.88
- Percentile
- 100%
- References
- 118
Authors
16- CACharalambos AntoniadesCorresponding
University of Oxford
- DTDimitris Tousoulis
National and Kapodistrian University of Athens, Frontier Science Foundation-Hellas
- MVMarija Vavlukis
Ss. Cyril and Methodius University in Skopje
- IFIngrid Fleming
Goethe University Frankfurt
- DJDirk J. Duncker
Erasmus MC, Erasmus University Rotterdam
Topics & keywords
- Medicine
- Adipose tissue
- Pathology
- Intensive care medicine
- Internal medicine
- Good health and well-being