Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments

Extracellular communication, in other words, crosstalk between cells, has a pivotal role in the survival of an organism. This communication occurs by different methods, one of which is extracellular vesicles. Exosomes, which are small lipid extracellular vesicles, have recently been discovered to have a role in signal transduction between cells inside the body. These vesicles contain important bioactive molecules including lipids, proteins, DNA, mRNA, and noncoding RNAs such as microRNAs (miRNAs). Exosomes are secreted by all cells including immune cells (macrophages, lymphocytes, granulocytes, dendritic cells, mast cells) and tumor cells. The tumor microenvironment (TME) represents a complex network that…

• MO
  Ministry of Science and Technology, Taiwan

  Awards: 111-2221-E-005-009, MOST 111-2221-E-005-026-MY3, 110-2221-E-005-010, MOST 110-2221-E-005-010, MOST 111-2221-E-005-009, 111-2221-E-005-026-MY3