Lipid-Based Nanoparticles for Drug/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development
University of Technology Sydney · The University of Sydney · +2 more institutions
Abstract
Over the past decade, the therapeutic potential of nanomaterials as novel drug delivery systems complementing conventional pharmacology has been widely acknowledged. Among these nanomaterials, lipid-based nanoparticles (LNPs) have shown remarkable pharmacological performance and promising therapeutic outcomes, thus gaining substantial interest in preclinical and clinical research. In this review, we introduce the main types of LNPs used in drug formulations such as liposomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and lipid polymer hybrid nanoparticles, focusing on their main physicochemical properties and therapeutic potential. We discuss computational studies and modeling…
Citation impact
- FWCI
- 60.40
- Percentile
- 100%
- References
- 217
Authors
6Topics & keywords
- Nanotechnology
- Drug delivery
- Commercialization
- Biochemical engineering
- Computer science
- Risk analysis (engineering)
- Materials science
- Medicine
- Industry, innovation and infrastructure