Postacute sequelae of COVID-19 at 2 years

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to postacute sequelae in multiple organ systems, but evidence is mostly limited to the first year postinfection. We built a cohort of 138,818 individuals with SARS-CoV-2 infection and 5,985,227 noninfected control group from the US Department of Veterans Affairs and followed them for 2 years to estimate the risks of death and 80 prespecified postacute sequelae of COVID-19 (PASC) according to care setting during the acute phase of infection. The increased risk of death was not significant beyond 6 months after infection among nonhospitalized but remained significantly elevated through the 2 years in hospitalized individuals. Within…

• UD
  U.S. Department of Veterans Affairs

  Awards: SDR 02-237, SDR 02-237 and 98-004, 98-004
• OO
  Office of Research and Development
• HS
  Health Services Research and Development

  Award: SDR 02-237