Mitochondria-associated programmed cell death as a therapeutic target for age-related disease
Yonsei University · Gwangju Institute of Science and Technology · +8 more institutions
Abstract
Mitochondria, ubiquitous double-membrane-bound organelles, regulate energy production, support cellular activities, harbor metabolic pathways, and, paradoxically, mediate cell fate. Evidence has shown mitochondria as points of convergence for diverse cell death-inducing pathways that trigger the various mechanisms underlying apoptotic and nonapoptotic programmed cell death. Thus, dysfunctional cellular pathways eventually lead or contribute to various age-related diseases, such as neurodegenerative, cardiovascular and metabolic diseases. Thus, mitochondrion-associated programmed cell death-based treatments show great therapeutic potential, providing novel insights in clinical trials. This review discusses…
Citation impact
- FWCI
- 61.28
- Percentile
- 100%
- References
- 136
Authors
16- TTThanh Tùng Nguyễn
Yonsei University, Gwangju Institute of Science and Technology
- SWShibo Wei
Sungkyunkwan University
- THThu Ha Nguyen
Yonsei University, Gwangju Institute of Science and Technology
- YJYunju Jo
Gwangju Institute of Science and Technology
- YZYan Zhang
Sungkyunkwan University
Topics & keywords
- Necroptosis
- Programmed cell death
- Mitochondrion
- Mitophagy
- Pyroptosis
- Cell biology
- Biology
- Cell