A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) and a hypoxia-responsive prodrug for multifunctional image-guided combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence and photoacoustic (PA) brightness for the strong light absorption ability, as well as amplified type I and type II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating the high-performance AIEgen with a hypoxia-responsive paclitaxel (PTX) prodrug into nanoparticles, and further…

• NN
  National Natural Science Foundation of China

  Awards: 82102200, 52103168, 82172081
• NU
  Nankai University
• SK
  State Key Laboratory of Medicinal Chemical Biology

  Award: 2022002
• NN
  National Natural Science Foundation of China-Yunnan Joint Fund

  Awards: 52103168, 82102200, 82172081
• FR
  Fundamental Research Funds for the Central Universities

  Awards: 63231199, 2021-RC350-006, 63233052
• CA
  Chinese Academy of Medical Sciences Initiative for Innovative Medicine

  Award: 2021-I2M-1-043