Hot and cold tumors: Immunological features and the therapeutic strategies
Shanghai University of Traditional Chinese Medicine · Hanalei Watershed Hui · +4 more institutions
Abstract
The "hotness" or "coldness" of the tumors are determined by the information of the cancer cells themselves, tumor immune characteristics, tumor microenvironment, and signaling mechanisms, which are key factors affecting cancer patients' clinical efficacy. The switch mechanism of "hotness" and "coldness" and its corresponding pathological characteristics and treatment strategies are the frontier and hot spot of tumor treatment. How to distinguish the "hotness" or "coldness" effectively and clarify the causes, microenvironment state, and characteristics are very important for the tumor response and efficacy treatments. Starting from the concept of hot and cold tumor, this review systematically summarized the…
Citation impact
- FWCI
- 44.38
- Percentile
- 100%
- References
- 261
Authors
10- LWLianjie Wang
Shanghai University of Traditional Chinese Medicine, Hanalei Watershed Hui, Shuguang Hospital
- HGHui Geng
Shanghai International Medical Center, Hanalei Watershed Hui
- YLYujie Liu
Shanghai University of Traditional Chinese Medicine, Hanalei Watershed Hui, Shuguang Hospital
- LLLei Liu
Shanghai University of Traditional Chinese Medicine, Shuguang Hospital
- YCYanhua Chen
Shanghai University of Traditional Chinese Medicine
Topics & keywords
- Tumor microenvironment
- Medicine
- Mechanism (biology)
- Hot spot (computer programming)
- Cancer
- Cancer research
- Clinical efficacy
- Immune system
- Good health and well-being