Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia
Brown University · Ethiopian Public Health Institute · +5 more institutions
Abstract
Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control and are pre-requisites for malaria elimination efforts; hence we need to monitor emergence, evolution and spread of drug- and diagnostics-resistant parasites. We deep sequenced key drug-resistance mutations and 1,832 SNPs in the parasite genomes of 609 malaria cases collected during a diagnostic-resistance surveillance study in Ethiopia. We found that 8.0% (95% CI 7.0-9.0) of malaria cases were caused by P. falciparum carrying the candidate artemisinin partial-resistance kelch13 (K13) 622I mutation, which was less common in diagnostic-resistant parasites mediated by histidine-rich proteins 2 and 3 (pfhrp2/3)…
Citation impact
- FWCI
- 50.43
- Percentile
- 100%
- References
- 52
Authors
16Topics & keywords
- Malaria
- Plasmodium falciparum
- Artemisinin
- Biology
- Virology
- Drug resistance
- Parasitology
- Genome
- Good health and well-being