Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, Minlan; Yang, Biao; Rothschild, Gerson; Mann, J. John; Sanford, Larry D.; Tang, Xiangdong; Huang, Canhua; Wang, Chuang; Zhang, Wei

doi:10.1038/s41392-023-01519-z

reviewSignal Transduction and Targeted TherapyAug 30, 2023GOLD OA

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

MYMinlan Yuan BYBiao Yang GRGerson Rothschild JJJ. John Mann LDLarry D. Sanford

Sichuan University · State Key Laboratory of Biotherapy · +6 more institutions

PubMed

Indexed incrossrefdoajpubmed

Abstract

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease that affects an estimated 300 million people worldwide, but its pathogenesis is poorly understood. The heritability estimate of MDD is 30-40%, suggesting that genetics alone do not account for most of the risk of major depression. Another factor known to associate with MDD involves environmental stressors such as childhood adversity and recent life stress. Recent studies have emerged to show that the biological impact of environmental factors in MDD and other stress-related disorders is mediated by a variety of epigenetic modifications. These epigenetic modification alterations contribute to abnormal neuroendocrine…

Citation impact

192

total citations

FWCI: 30.42
Percentile: 100%
References: 508

Citations per year

Authors

9

Topics & keywords

Topics

Keywords

Epigenetics
Major depressive disorder
DNA methylation
Bioinformatics
Chromatin remodeling
Neuroscience
Medicine
Psychology

No related works found for this paper.